As a part of a group module during my second year of Uni I was tasked with creating 4 characters for our multiplayer game using concepts made for the game. I mainly used ZBrush to create the characters but I originally started in 3DS Max to make the blockout and give myself a good starting point to start sculpting on top of.
Disclaimer: the concepts shown are not my work and were created by two other people in my group, I have added them so it's clear to see what the aim for the character was.